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Pharming for Genes in Neurotransmission: Combining Chemical and Genetic Approaches in Caenorhabditis elegans
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1021/acschemneuro.7b00509
Stephen M. Blazie 1 , Yishi Jin 1
Affiliation  

Synaptic transmission is central to nervous system function. Chemical and genetic screens are valuable approaches to probe synaptic mechanisms in living animals. The nematode Caenorhabditis elegans is a prime system to apply these methods to discover genes and dissect the cellular pathways underlying neurotransmission. Here, we review key approaches to understand neurotransmission and the action of psychiatric drugs in C. elegans. We start with early studies on cholinergic excitatory signaling at the neuromuscular junction, and move into mechanisms mediated by biogenic amines. Finally, we discuss emerging work toward understanding the mechanisms driving synaptic plasticity with a focus on regulation of protein translation.

中文翻译:

神经传递中的基因修饰:秀丽隐杆线虫的化学和遗传方法相结合

突触传递对神经系统功能至关重要。化学和遗传筛选是探测活体动物突触机制的有价值的方法。线虫秀丽隐杆线虫是应用这些方法发现基因并解剖神经传递基础的细胞途径的主要系统。在这里,我们回顾了了解线虫中神经传递和精神药物作用的关键方法。我们从对神经肌肉连接处胆碱能兴奋性信号转导的早期研究开始,并进入由生物胺介导的机制。最后,我们讨论了新兴的工作,以了解驱动突触可塑性的机制,重点是蛋白质翻译的调控。
更新日期:2018-02-12
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