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Multifunctional Biomaterial Coating Based on Bio-Inspired Polyphosphate and Lysozyme Supramolecular Nanofilm
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1021/acs.biomac.8b00002 Xinyuan Xu 1 , Dongyue Zhang 1 , Shangwei Gao 1 , Toshikazu Shiba 2 , Quan Yuan 3 , Kai Cheng 1 , Hong Tan 1 , Jianshu Li 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1021/acs.biomac.8b00002 Xinyuan Xu 1 , Dongyue Zhang 1 , Shangwei Gao 1 , Toshikazu Shiba 2 , Quan Yuan 3 , Kai Cheng 1 , Hong Tan 1 , Jianshu Li 1
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Current implant materials have widespread clinical applications together with some disadvantages, the majority of which are the ease with which infections are induced and difficulty in exhibiting biocompatibility. For the efficient improvement of their properties, the development of interface multifunctional modification in a simple, universal, and environmently benign approach becomes a critical challenge and has acquired the attention of numerous scientists. In this study, a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based biomaterial to obtain a multifunctional surface. This coating was easily formed by sequentially soaking the substrate in reduced-lysozyme and polyphosphate solution. Such a composite coating has shown predominant antibacterial activity against Gram-negative bacteria (E. coli) and improved cell adhesion, proliferation, and differentiation, which are much better than those of the pure substrate. This facile modification endows the biomaterial with anti-infective and potential bone-regenerative performance for clinical applications of biomaterial implants.
中文翻译：
基于生物启发性聚磷酸盐和溶菌酶超分子纳米膜的多功能生物材料涂层
当前的植入物材料具有广泛的临床应用以及一些缺点，其中大多数是诱发感染的容易性和表现出生物相容性的困难。为了有效地改善其性能，以简单，通用且环境友好的方法开发界面多功能修饰已成为一项严峻的挑战，并引起了众多科学家的关注。在这项研究中，针对钛（Ti）基生物材料制备了溶菌酶-聚磷酸盐复合涂层，以获得多功能表面。通过将底物顺序浸入溶菌酶和多磷酸盐溶液中，可以轻松形成该涂层。这种复合涂层对革兰氏阴性细菌显示出主要的抗菌活性（大肠杆菌（E. coli）和改善的细胞黏附，增殖和分化，这要比纯底物好得多。这种简便的修饰使生物材料具有抗感染和潜在的骨再生性能，可用于生物材料植入物的临床应用。
更新日期：2018-02-12
中文翻译：
基于生物启发性聚磷酸盐和溶菌酶超分子纳米膜的多功能生物材料涂层
当前的植入物材料具有广泛的临床应用以及一些缺点，其中大多数是诱发感染的容易性和表现出生物相容性的困难。为了有效地改善其性能，以简单，通用且环境友好的方法开发界面多功能修饰已成为一项严峻的挑战，并引起了众多科学家的关注。在这项研究中，针对钛（Ti）基生物材料制备了溶菌酶-聚磷酸盐复合涂层，以获得多功能表面。通过将底物顺序浸入溶菌酶和多磷酸盐溶液中，可以轻松形成该涂层。这种复合涂层对革兰氏阴性细菌显示出主要的抗菌活性（大肠杆菌（E. coli）和改善的细胞黏附，增殖和分化，这要比纯底物好得多。这种简便的修饰使生物材料具有抗感染和潜在的骨再生性能，可用于生物材料植入物的临床应用。
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