Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.

中文翻译：

---

神经鞘瘤中的HIPPO踩踏事件。

目前用于恶性周围神经鞘瘤（MPNST）的疗法无效。吴等人的研究。本期《癌细胞》杂志上的证据提供了证据，表明HIPPO途径在人MPNSTs中过度活跃，并且雪旺细胞中LATS1 / 2-YAP / TAZ和PDGFR信号转导的联合调节降低了MPNST的生长。