Completion of early stages of tumorigenesis relies on the dynamic interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.

中文翻译：

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细胞柔韧性和肿瘤发生的多步过程。

肿瘤发生早期阶段的完成取决于起始致癌事件与细胞环境之间的动态相互作用。在这里，我们回顾了最近的发现，这些发现表明，在遭受特定的致癌侵害时，定义的细胞谱系内的每个分化阶段都与恶性转化的独特易感性相关。这个新兴的概念，称为细胞柔顺性，为产前起源的小儿癌症发展的短暂延迟提供了理论依据。它还强调了细胞重编程在成年分化细胞恶性转化的早期阶段中的关键作用及其对肿瘤发生自然史的影响。