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One-step sonochemical synthesis of 1D β-Stannous Tungstate Nanorods: An efficient and excellent electrocatalyst for the selective electrochemical detection of antipsychotic drug chlorpromazine
Ultrasonics Sonochemistry ( IF 8.4 ) Pub Date : 2018-02-12 , DOI: 10.1016/j.ultsonch.2018.02.025
Thangavelu Kokulnathan , Jeyaraj Vinoth Kumar , Shen-Ming Chen , Raj Karthik , Arumugam Elangovan , Velluchamy Muthuraj

In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary task to the precise detection of drugs. With this regards, we made an effort for the fabrication of novel one-dimensional (1D) stannous tungstate nanorods (β-SnW NRs) via simple sonochemical approach and used as an electrochemical sensor for the detection of antipsychotic drug chlorpromazine (CPZ) for the first time. The crystallographic structure, surface topology, elemental compositions and their distributions and ionic states were enquired by different spectroscopic techniques such as XRD, FTIR, SEM, EDS, elemental mapping and XPS analysis. The developed β-SnW NRs/GCE sensor exhibits a rapid and sensitive electrochemical response towards CPZ sensing with wide linear response range (0.01 - 457 µM), high sensitivity (2.487 µA µM-1cm-2), low detection limit (0.003 µM) and excellent selectivity. Besides, the as-proposed electrochemical sensor was successfully applied to real sample analysis in commercial CPZ drug and biological fluids and the acquired recovery results are quite satisfactory. The proposed sonochemical method for the preparation of β-SnW NRs is low cost, very simple, fast and efficient for sensor applications.



中文翻译:

一步法声化学合成一维β-亚锡钨酸盐纳米棒:一种高效,优异的电催化剂,用于选择性电化学检测抗精神病药物氯丙嗪

在现代世界中,人类和兽药通过代谢排泄,不当处置/工业废物对生态系统的污染一直是一个热门问题。因此,开发专有的结构材料和可靠的技术是精确检测药物的必要任务。考虑到这一点,我们努力通过简单的声化学方法制备新型一维(1D)钨酸锡纳米棒(β-SnWNRs),并将其用作电化学传感器,用于检测抗精神病药氯丙嗪(CPZ)。第一次。通过不同的光谱技术,如XRD,FTIR,SEM,EDS,元素图谱和XPS分析,查询了晶体结构,表面拓扑,元素组成及其分布和离子态。-1 cm -2),低检测限(0.003 µM)和出色的选择性。此外,所提出的电化学传感器已成功地应用于商业CPZ药物和生物液体中的真实样品分析,并且获得的回收率结果令人满意。所提出的用于制备β-SnWNRs的声化学方法成本低廉,对于传感器应用非常简单,快速且高效。

更新日期:2018-02-13
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