Influenza epidemics and pandemics still represent a severe public health threat and cause significant morbidity and mortality worldwide. As intracellular parasites, influenza viruses are strongly dependent on the host cell machinery. To ensure efficient production of progeny viruses, viral proteins extensively interfere with cellular signalling pathways to inhibit antiviral responses or to activate virus-supportive functions. Here, we review various functions of the influenza virus nonstructural proteins NS1, PB1-F2, and PA-X in infected cells and how post-transcriptional modifications of these proteins affect the viral life cycle. Furthermore, we discuss newly discovered interactions between these proteins and the antiviral interferon response.

流感流行和大流行仍然是严重的公共卫生威胁，并在全世界造成显着的发病率和死亡率。作为细胞内寄生虫，流感病毒强烈依赖于宿主细胞机制。为了确保子代病毒的有效生产，病毒蛋白广泛干扰细胞信号传导途径，以抑制抗病毒反应或激活病毒支持功能。在这里，我们回顾了流感病毒非结构蛋白 NS1、PB1-F2 和 PA-X 在受感染细胞中的各种功能，以及这些蛋白的转录后修饰如何影响病毒生命周期。此外，我们讨论了这些蛋白质与抗病毒干扰素反应之间新发现的相互作用。