Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing impairment; therefore, treatments to improve hemodynamics and increase wound oxygenation are of particular interest for the treatment of chronic wounds. This article describes the roles of oxygen and angiogenesis in wound healing as well as the tools used to evaluate tissue oxygenation and perfusion and then presents a review of nanomedicines and gene therapies designed to improve perfusion and oxygenation and accelerate wound healing.

中文翻译：

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纳米药物和基因疗法可用于输送生长因子，以改善伤口愈合中的灌注和氧合

氧气在伤口愈合中起关键作用，缺氧是伤口愈合受损的主要原因。因此，对于慢性伤口的治疗特别关注改善血液动力学和增加伤口氧合的治疗。本文介绍了氧气和血管生成在伤口愈合中的作用，以及用于评估组织氧合和灌注的工具，然后介绍了旨在改善灌注和氧合并加速伤口愈合的纳米药物和基因疗法。