Ionic liquids are a class of solvents and materials that hold great promise in bioanalytical chemistry. Task-specific ionic liquids have recently been designed for the selective extraction, separation, and detection of proteins, peptides, nucleic acids, and other physiologically relevant analytes from complex biological samples. To facilitate rapid bioanalysis, ionic liquids have been integrated in miniaturized and automated procedures. Bioanalytical separations have also benefited from the modification of nonspecific magnetic materials with ionic liquids or the implementation of ionic liquids with inherent magnetic properties. Furthermore, the direct detection of the extracted molecules in the analytical instrument has been demonstrated with structurally tuned ionic liquids and magnetic ionic liquids, providing a significant advantage in the analysis of low-abundance analytes. This article gives an overview of these advances that involve the application of ionic liquids and derivatives in bioanalysis.

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离子液体是一类在生物分析化学中具有广阔前景的溶剂和材料。任务专用的离子液体最近被设计用于从复杂的生物样品中选择性提取，分离和检测蛋白质，肽，核酸和其他生理相关分析物。为了促进快速的生物分析，已将离子液体集成到小型化和自动化程序中。生物分析分离还受益于用离子液体对非特异性磁性材料的改性或实施具有固有磁性的离子液体。此外，通过结构调整的离子液体和磁性离子液体已经证明了在分析仪器中直接检测提取的分子，在分析低丰度分析物方面提供了显着优势。本文概述了这些进展，这些进展涉及离子液体及其衍生物在生物分析中的应用。

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