A simple voltammetric nanosensor was described for the highly sensitive determination of antiviral drug Tenofovir. The benzalkonium chloride and silver nanoparticles were associated to build a nanosensor on glassy carbon electrode. Surface characterictics were achieved using scanning electron microscopic technique. The voltammetric measurements were performed in pH range between 1.0 and 10.0 using cyclic, adsorptive stripping differential pulse and adsorptive stripping square wave voltammetry. The linear dependence of the peak current on the square root of scan rates and the slope value (0.770) demonstrated that the oxidation of tenofovir is a mix diffusion‐adsorption controlled process in pH 5.70 acetate buffer. The linearity range was found to be 6.0×10⁻⁸–1.0×10⁻⁶ M, and nanosensor displayed an excellent detection limit of 2.39×10⁻⁹ M by square wave adsorptive stripping voltammetry. The developed nanosensor was successfully applied for the determination of Tenofovir in pharmaceutical dosage form. Moreover, the voltammetric oxidation pathway of tenofovir was also investigated at bare glassy carbon electrode comparing with some possible model compounds (Adenine and Adefovir).

中文翻译：

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基于纳米银-苯扎氯铵的电化学传感器伏安法测定替诺福韦

描述了一种简单的伏安纳米传感器，用于高灵敏度测定抗病毒药物替诺福韦。苯扎氯铵和银纳米粒子被关联以在玻璃碳电极上建立纳米传感器。使用扫描电子显微镜技术获得表面特性。伏安法的测量是在1.0至10.0的pH范围内，使用循环，吸附溶出差动脉冲和吸附溶出方波伏安法进行的。峰值电流对扫描速率平方根和斜率值（0.770）的线性依赖性表明，替诺福韦的氧化是pH 5.70醋酸盐缓冲液中混合扩散-吸附控制的过程。线性范围为6.0×10 ^-8 –1.0×10 ^-6 M和纳米传感器 通过方波吸附溶出伏安法显示出2.39×10 ^-9 M的极佳检测限。研制成功的纳米传感器已成功应用于药物剂型替诺福韦的测定。此外，还与一些可能的模型化合物（腺嘌呤和阿德福韦）相比，研究了替诺福韦在裸露玻碳电极上的伏安氧化途径。