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Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review
Analytical Methods ( IF 2.7 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1039/c7ay02686b
M. A. L. Oliveira 1, 2, 3, 4 , P. R. Chellini 2, 3, 4, 5 , T. L. Amorim 1, 2, 3, 4
Affiliation  

According to the World Health Organization, rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride are the first-line drugs used to treat tuberculosis – an infectious disease caused by Mycobacterium tuberculosis. Since 2010, tuberculosis has been treated with a fixed-dose combination containing the four drugs in only one tablet, called 4-FDC, which has simplified the treatment, minimized prescription errors and increased patients' adherence to their treatment regime. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to simultaneous 4-FDC content determination in pharmaceutical formulations, such as high performance liquid chromatography, ultrahigh performance liquid chromatography, thin layer chromatography and capillary electrophoresis as separation techniques and molecular spectroscopic techniques associated with chemometric approaches, such as UV, Raman, Fourier transform infrared and near infrared.

中文翻译:

同时测定固定剂量联合抗结核药物制剂中的利福平,异烟肼,吡嗪酰胺和乙胺丁醇:综述

根据世界卫生组织的资料,利福平,异烟肼,吡嗪酰胺和盐酸乙胺丁醇是用于治疗结核病的一线药物,结核病是由结核分枝杆菌引起的传染病。自2010年以来,结核病已通过固定剂量的组合治疗,该组合仅在一种称为4-FDC的片剂中包含四种药物,从而简化了治疗,减少了处方错误并增加了患者对治疗方案的依从性。在此背景下,本综述旨在显示已应用于药物制剂中同时4-FDC含量测定的不同分析方法的演变,例如高效液相色谱法,超高效液相色谱法,薄层色谱法和毛细管电泳法。与化学计量学方法相关的分离技术和分子光谱技术,例如UV,拉曼,傅立叶变换红外光谱和近红外光谱。
更新日期:2018-02-12
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