Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy†,Biomaterials Science

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Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1039/c7bm01114h
Lin Liu _{1,

2,

3,

4} , Ruibo Wang _{5,

6,

7,

8} , Chunran Wang _{1,

2,

3,

4} , Jinze Wang _{1,

2,

3,

4} , Li Chen _{1,

2,

3,

4} , Jianjun Cheng _{5,

6,

7,

8}

Affiliation

Herein, we present a series of light-triggered porphyrin-based polymeric drug conjugates PSDTD-m for combined chemo-photodynamic therapy of cancer. The controlled release of a drug through a ROS-cleavable linker combined with photodynamic therapy showed enhanced anticancer efficacy, proving the effectiveness of this light triggered smart nanocarrier platform for enhancing the therapy efficacy.

中文翻译：

光触发释放药物结合物，实现化学疗法和光动力疗法的有效结合†

在本文中，我们提出了一系列光触发的基于卟啉的聚合物药物共轭物PSDTD - m，用于癌症的化学光动力疗法的联合治疗。通过ROS可裂解的连接基与光动力疗法相结合的药物控制释放显示出增强的抗癌功效，证明了这种光触发的智能纳米载体平台可提高治疗功效。

更新日期：2018-02-12

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