In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C‐bpy)₂/mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C‐bpy)₂/mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C‐bpy)₂ alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C‐bpy)₂/mLDH is possessed of two‐photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C‐bpy)₂/mLDH can generate singlet oxygen with a high yield (φ_∆) of 0.28 under the 520 nm irradiation, while the φ_∆ of Ru(C‐bpy)₂ is 0.19. Therefore, the Ru(C‐bpy)₂/mLDH can be applied as a supramolecular theranostic agent with light‐switchable cancer imaging and photodynamic therapy properties.

中文翻译：

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激发依赖的治疗学纳米片用于癌症治疗

在这项工作中，合成了一种新型的负载钌复合物的单层双层双氢氧化物（LDH）（表示为Ru（C-bpy）₂ / mLDH）作为超分子纳米传感器，这是低氧肿瘤微环境所独有的。与单独的母体Ru（C-bpy）₂相比，Ru（C-bpy）₂ / mLDH超薄片不仅显示出更长的发光寿命，而且在488或800 nm的激发下还改善了氧气的吸收能力。此外，Ru（C-bpy）₂ / mLDH在800 nm辐射下具有双光子荧光成像能力。此外，在Ru（C-联吡啶）₂ / MLDH可以产生具有高的产率（φ单线态氧_Δ 0.28 520纳米辐射下），而φRu（C-bpy）_2的∆为0.19。因此，Ru（C-bpy）₂ / mLDH可以用作具有光可切换癌症成像和光动力疗法特性的超分子治疗剂。