We report the synthesis and analytical application of the first Cu²⁺‐selective synthetic ion channel based on peptide‐modified gold nanopores. A Cu²⁺‐binding peptide motif (Gly‐Gly‐His) along with two additional functional thiol derivatives inferring cation‐permselectivity and hydrophobicity was self‐assembled on the surface of gold nanoporous membranes comprising of about 5 nm diameter pores. These membranes were used to construct ion‐selective electrodes (ISEs) with extraordinary Cu²⁺ selectivities, approaching six orders of magnitude over certain ions. Since all constituents are immobilized to a supporting nanoporous membrane, their leaching, that is a ubiquitous problem of conventional ionophore‐based ISEs was effectively suppressed.

中文翻译：

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基于亲水性离子载体修饰纳米孔的离子选择电极

我们报道了第一个基于肽修饰金纳米孔的Cu ²⁺选择性合成离子通道的合成和分析应用。Cu ²⁺结合肽基序（Gly-Gly-His）与两个额外的功能性硫醇衍生物（具有阳离子选择性渗透性和疏水性）一起自组装在由直径约 5 nm 的孔组成的金纳米多孔膜的表面上。这些膜用于构建具有非凡 Cu ²⁺选择性的离子选择性电极（ISE），比某些离子接近六个数量级。由于所有成分都固定在支撑性纳米多孔膜上，因此传统基于离子载体的 ISE 普遍存在的浸出问题得到了有效抑制。