A series of novel 3‐substituted N‐methylcarbazole–imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of tumor cell lines (Hep G‐2, Hela and PC12). The results suggest that the presence of substituted 2‐methyl‐imidazole or imidazole ring and substitution of the imidazolyl‐3‐position with a naphthylacyl or 4‐bromophenacyl group were important for improving cytotoxic activity. Compounds 17, 18, 27, and 28 with 4‐bromophenacyl and naphthylacyl groups displayed good activities with IC₅₀ values of 0.09–7.20 μm against three tumor cell lines investigated and more active than DDP. Compound 35 exhibited cytotoxic activity selectively against Hela cell.

中文翻译：

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新型3-取代的N-甲基咔唑-咪唑鎓盐衍生物：合成和细胞毒性活性

已经制备了一系列新颖的3-取代的N-甲基咔唑-咪唑鎓盐衍生物，并针对一组肿瘤细胞系（Hep G-2，Hela和PC12）进行了体外评估。结果表明，取代的2-甲基咪唑或咪唑环的存在以及咪唑基-3-位置被萘甲酰基或4-溴苯甲酰基取代对于提高细胞毒性活性很重要。化合物17，18，27，和28与4-溴苯甲酰和naphthylacyl基团表现出良好的活性与IC _50个的0.09-7.20μ值米针对三种肿瘤细胞系研究和比DDP更活跃。化合物35 表现出针对Hela细胞的选择性细胞毒活性。