Background

Whether the underlying disease affects the outcomes in pyoderma gangrenosum (PG) is unclear.

Objectives

To determine the impact of comorbid disease associations and concomitant procedural treatments on patient outcomes in hospitalizations of patients with PG.

Methods

A cross-sectional analysis of the National Inpatient Sample for hospitalizations of patients with PG from the years 2002 to 2011, analyzing in-hospital mortality rate and health care resource utilization.

Results

Inflammatory bowel disease was the most frequent comorbid association, followed by inflammatory arthritis, hematologic malignancies/dyscrasia, and vasculitis. Multivariable modeling showed that vasculitis and hematologic malignancy/dyscrasia, when compared with inflammatory bowel disease, were associated with a 4-fold to 6-fold increased risk of in-hospital mortality and increasing health care resource utilization. Inpatient procedural interventions, including skin grafts, biopsies, and debridement, did not affect mortality and were associated with an increased length of stay.

Limitations

The database does not account for outpatient follow-up; additionally, there was a low rate of coded comorbid conditions.

Conclusions

Comprehensive evaluation to determine the underlying comorbidity for patients with PG is important for patient risk stratification.

中文翻译：

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基础疾病状态对坏疽性脓皮病患者预后的影响：一项全国性调查

背景

潜在疾病是否影响坏疽性脓皮病 (PG) 的结果尚不清楚。

目标

确定共存疾病关联和伴随程序治疗对 PG 患者住院治疗结果的影响。

方法

2002 年至 2011 年全国 PG 患者住院样本的横断面分析，分析住院死亡率和医疗资源利用情况。

结果

炎症性肠病是最常见的合并症，其次是炎症性关节炎、血液系统恶性肿瘤/恶液质和血管炎。多变量模型显示，与炎症性肠病相比，血管炎和血液系统恶性肿瘤/恶液质与住院死亡率风险增加 4 至 6 倍以及医疗资源利用率增加相关。住院程序干预，包括皮肤移植、活检和清创，不影响死亡率，并且与住院时间延长有关。

限制

该数据库不考虑门诊随访；此外，编码合并症的发生率很低。

结论

综合评估以确定 PG 患者的潜在合并症对于患者风险分层很重要。