In this study, we have developed a facile method for preparation of highly fluorescent Au nanoclusters (AuNCs) using 11-mercaptoundecanoic acid (MUA) as both the reducing and stabilizing agent. The as-prepared MUA functionalized AuNCs (MUA-AuNCs) have good water solubility, excellent photostability, and strong fluorescence emission at 610 nm with a quantum yield of 7.28% in water. The fluorescence of MUA-AuNCs was first quenched by copper ions through electron transfer, subsequently caused obvious restoration by competitive effect after adding penicillamine, making it a potential fluorescent sensor for penicillamine with a detection limit of 0.08 μM. Furthermore, the newly designed fluorescence “on-off-on” assay was explored for the measurement of penicillamine in complex real water and urine samples with satisfactory results.

在这项研究中，我们已经开发了一种使用11-巯基癸酸（MUA）作为还原剂和稳定剂的高荧光金纳米簇（AuNCs）的制备方法。所制备的MUA功能化AuNCs（MUA-AuNCs）具有良好的水溶性，优异的光稳定性和在610 nm处的强荧光发射，在水中的量子产率为7.28％。MUA-AuNCs的荧光首先通过电子转移被铜离子猝灭，随后在加入青霉胺后通过竞争作用引起明显的恢复，使其成为潜在的青霉素胺荧光传感器，检测限为0.08μM。此外，探索了新设计的荧光“ on-off-on”测定法，用于测量复杂的真实水和尿液样品中的青霉素胺，结果令人满意。