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Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for In Vivo Clearance of Radiation‐Induced ROS via Surface‐Mediated Bond Breaking
Small ( IF 13.0 ) Pub Date : 2018-02-09 , DOI: 10.1002/smll.201703736 Jun-Ying Wang 1 , Xiaoyu Mu 1 , Yonghui Li 1 , Fujuan Xu 1 , Wei Long 2 , Jiang Yang 3 , Peixian Bian 2 , Junchi Chen 1 , Lufei Ouyang 1 , Haile Liu 1 , Yaqi Jing 1 , Jingya Wang 2 , Lingfang Liu 1 , Haitao Dai 1 , Yuanming Sun 2 , Changlong Liu 1 , Xiao-Dong Zhang 1
Small ( IF 13.0 ) Pub Date : 2018-02-09 , DOI: 10.1002/smll.201703736 Jun-Ying Wang 1 , Xiaoyu Mu 1 , Yonghui Li 1 , Fujuan Xu 1 , Wei Long 2 , Jiang Yang 3 , Peixian Bian 2 , Junchi Chen 1 , Lufei Ouyang 1 , Haile Liu 1 , Yaqi Jing 1 , Jingya Wang 2 , Lingfang Liu 1 , Haitao Dai 1 , Yuanming Sun 2 , Changlong Liu 1 , Xiao-Dong Zhang 1
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Catalytic nanomaterials can be used extrinsically to combat diseases associated with a surplus of reactive oxygen species (ROS). Rational design of surface morphologies and appropriate doping can substantially improve the catalytic performances. In this work, a class of hollow polyvinyl pyrrolidone‐protected PtPdRh nanocubes with enhanced catalytic activities for in vivo free radical scavenging is proposed. Compared with Pt and PtPd counterparts, ternary PtPdRh nanocubes show remarkable catalytic properties of decomposing H2O2 via enhanced oxygen reduction reactions. Density functional theory calculation indicates that the bond of superoxide anions breaks for the energetically favorable status of oxygen atoms on the surface of PtPdRh. Viability of cells and survival rate of animal models under exposure of high‐energy γ radiation are considerably enhanced by 94% and 50% respectively after treatment of PtPdRh nanocubes. The mechanistic investigations on superoxide dismutase (SOD) activity, malondialdehyde amount, and DNA damage repair demonstrate that hollow PtPdRh nanocubes act as catalase, peroxidase, and SOD analogs to efficiently scavenge ROS.
中文翻译：
具有增强催化活性的空心PtPdRh纳米立方体，可通过表面介导的键断裂来体内清除辐射诱导的ROS
催化纳米材料可用于预防与过量活性氧（ROS）相关的疾病。表面形态的合理设计和适当的掺杂可以大大提高催化性能。在这项工作中，提出了一类具有增强的体内清除自由基活性的催化活性的中空聚乙烯吡咯烷酮保护的PtPdRh纳米立方体。与Pt和PtPd对应物相比，三元PtPdRh纳米立方体显示出显着的分解H 2 O 2的催化性能。通过增强的氧气还原反应。密度泛函理论计算表明，PtPdRh表面的氧原子在能量上处于有利的状态，因此超氧阴离子的键断裂。处理PtPdRh纳米立方体后，高能γ射线暴露下的细胞活力和动物模型的存活率分别显着提高了94％和50％。对超氧化物歧化酶（SOD）活性，丙二醛含量和DNA损伤修复的机理研究表明，空心PtPdRh纳米立方体可充当过氧化氢酶，过氧化物酶和SOD类似物，以有效清除ROS。
更新日期：2018-02-09
中文翻译：
具有增强催化活性的空心PtPdRh纳米立方体，可通过表面介导的键断裂来体内清除辐射诱导的ROS
催化纳米材料可用于预防与过量活性氧（ROS）相关的疾病。表面形态的合理设计和适当的掺杂可以大大提高催化性能。在这项工作中，提出了一类具有增强的体内清除自由基活性的催化活性的中空聚乙烯吡咯烷酮保护的PtPdRh纳米立方体。与Pt和PtPd对应物相比，三元PtPdRh纳米立方体显示出显着的分解H 2 O 2的催化性能。通过增强的氧气还原反应。密度泛函理论计算表明，PtPdRh表面的氧原子在能量上处于有利的状态，因此超氧阴离子的键断裂。处理PtPdRh纳米立方体后，高能γ射线暴露下的细胞活力和动物模型的存活率分别显着提高了94％和50％。对超氧化物歧化酶（SOD）活性，丙二醛含量和DNA损伤修复的机理研究表明，空心PtPdRh纳米立方体可充当过氧化氢酶，过氧化物酶和SOD类似物，以有效清除ROS。
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