A strategy has been developed for the synthesis of pharmaceutically relevant spiroindolenines in a single step that proceeds through a sequential Prins/Friedel–Crafts cyclization. A 3‐({[2‐(1H‐indol‐3‐yl)ethyl]amino}methyl)but‐3‐en‐1‐ol derivative and various aldehydes react under mild conditions, leading to the products in good yields with high diastereoselectivity (Ns: 2‐nitrobenzenesulfonyl, TFA: trifluoroacetic acid, DCM: dichloromethane).

中文翻译：

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通过Prins / Friedel-Crafts环化级联反应立体构筑螺-吲哚骨架。

已经开发了一种策略，可通过一步的Prins / Friedel-Crafts环化过程一步合成合成药物相关的螺环吲哚胺。3-（{[[（2-（1 H-吲哚-3-基）乙基]氨基}甲基）丁-3-烯-1-醇衍生物与各种醛在温和的条件下反应，导致产物收率高高非对映选择性（Ns：2-硝基苯磺酰基，TFA：三氟乙酸，DCM：二氯甲烷）。