Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment.

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近来，用于分析生理生物标志物的可植入生物电子学已被认为是在医学治疗或诊断中有前途的技术。在这项研究中，我们开发了一种自供电的可植入皮肤样血糖仪，用于实时检测体内血糖水平。基于GOx @ ZnO纳米线的压电-酶反应耦合作用，该装置在施加变形后可以主动输出包含葡萄糖检测信息的压电信号。该设备不需要外部电源或电池，并且输出的压电电压既是生物传感信号又是电力。简单地证明了植入小鼠体内的皮肤样血糖仪在检测血糖水平方面的实际应用。

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