Introduction Retroperitoneal sarcoma (RPS) is a rare disease accounting for 0.1%-0.2% of all malignancies. Management of RPS is complex and requires multidisciplinary, tailored treatment strategies at all stages, but especially in the context of metastatic or multifocal recurrent disease. Due to the rarity and heterogeneity of this family of diseases, the literature to guide management is limited. Methods The Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG) is an international collaboration of sarcoma experts from all disciplines convened in an effort to overcome these limitations. The TARPSWG has compiled the available evidence surrounding metastatic and multifocally recurrent RPS along with expert opinion in an iterative process to generate a consensus document regarding the complex management of this disease. The objective of this document is to guide sarcoma specialists from all disciplines in the diagnosis and treatment of multifocal recurrent or metastatic RPS. Results All aspects of patient assessment, diagnostic processes, local and systemic treatments, and palliation are reviewed in this document, and consensus recommendations provided accordingly. Recommendations were guided by available evidence, in conjunction with expert opinion where evidence was lacking. Conclusions This consensus document combines the available literature regarding the management of multifocally recurrent or metastastic RPS with the practical expertise of high-volume sarcoma centers from multiple countries. It is designed as a tool for decision making in the complex multidisciplinary management of this condition and is expected to standardize management across centers, thereby ensuring that patients receive the highest quality care.

中文翻译：

---

转移性腹膜后肉瘤的管理：跨大西洋腹膜后肉瘤工作组（TARPSWG）的共识方法。

引言腹膜后肉瘤（RPS）是一种罕见疾病，占所有恶性肿瘤的0.1％-0.2％。RPS的管理很复杂，并且在所有阶段都需要多学科，量身定制的治疗策略，尤其是在转移性或多灶性复发性疾病的情况下。由于该疾病家族的稀有性和异质性，指导治疗的文献有限。方法跨大西洋腹膜后肉瘤工作组（TARPSWG）是由来自各个学科的肉瘤专家组成的国际合作组织，旨在克服这些局限性。TARPSWG在迭代过程中收集了有关转移性和多灶性复发性RPS的可用证据以及专家意见，以就该病的复杂治疗产生共识性文件。本文的目的是指导多学科复发或转移性RPS的诊断和治疗的各个学科的肉瘤专家。结果本文评估了患者评估，诊断过程，局部和全身治疗以及缓解的所有方面，并据此提供了共识性建议。建议以现有证据为指导，并结合缺乏证据的专家意见。结论该共识性文件结合了有关多灶性复发或转移性RPS治疗的现有文献以及来自多个国家的大量肉瘤中心的实际专业知识。它被设计为在这种情况下进行复杂的多学科管理的决策工具，并有望实现跨中心的标准化管理，