Female survivors of childhood cancer are at risk of late effects of their cancer treatment including increased risk of premature menopause before age 40 years (1). Premature menopause causes infertility at an early age, and also is linked to other adverse health outcomes such as heart disease and osteoporosis (2). Identifying biomarkers that define risk strata for treatment-associated premature menopause may allow survivors to partake in targeted medical interventions aimed to reduce or prevent the consequences of premature menopause, such as fertility preservation procedures and prevention programs for cardiovascular diseases and osteoporosis.

中文翻译：

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在儿童癌症幸存者中鉴定出更年期过早风险的生物标志物可能会导致有针对性的干预和健康策略。

儿童期癌症的女性幸存者可能会受到癌症治疗的后期影响，包括40岁之前更年期更早的风险增加（1）。绝经期过早会导致不孕，并且还与其他不良健康后果（如心脏病和骨质疏松症）相关（2）。鉴定定义与治疗相关的更年期风险等级的生物标志物，可使幸存者参与针对性的医学干预措施，以减少或预防更年期的后果，例如生育力保护程序以及心血管疾病和骨质疏松症的预防计划。