Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films†,Reaction Chemistry & Engineering

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Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2018-02-08 00:00:00 , DOI: 10.1039/c8re00002f
Kiran Iyer _{1,

2,

3,

4} , Jing Yi _{1,

2,

3,

4} , Andrew Bogdan _{4,

5,

6} , Nari Talaty _{4,

5,

6} , Stevan W. Djuric _{4,

5,

6} , R. Graham Cooks _{1,

2,

3,

4}

Affiliation

Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined liquid volumes in which accelerated air and water sensitive, heterogeneous, copper catalysed C–O and C–N coupling reactions occur. Significant reaction acceleration was observed compared to the bulk reaction which required elevated temperatures and time for completion. Macroscopic amounts of product (mg scale) were prepared using offline ES within minutes. The trends in reactivity observed for several reagents matched those of the bulk reactions making droplet accelerated reactions good mimics of the bulk chemistry.

中文翻译：

微滴和薄膜中加速的多试剂铜催化偶联反应†

电喷雾（ES）和纸喷雾（PS）质谱用于创建密闭液体体积，在其中发生加速的空气和水敏感，异质，铜催化的C–O和C–N偶联反应。与本体反应相比，观察到显着的反应加速，而本体反应需要升高的温度和完成时间。在几分钟内使用离线ES制备了宏观量的产品（毫克级）。几种试剂观察到的反应性趋势与本体反应的趋势相匹配，从而使液滴加速反应成为本体化学的良好模拟。

更新日期：2018-02-08

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