Cover Feature: Palladium‐Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2‐Arylbenzimidazoles “On Water” (Asian J. Org. Chem. 2/2018),Asian Journal of Organic Chemistry

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Cover Feature: Palladium‐Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2‐Arylbenzimidazoles “On Water” (Asian J. Org. Chem. 2/2018)
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-02-08 , DOI: 10.1002/ajoc.201800016
Hidemasa Hikawa ₁ , Risa Ichinose ₁ , Shoko Kikkawa ₁ , Isao Azumaya ₁

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On water: An environmentally benign one‐pot tandem reaction for the synthesis of 2‐arylbenzimidazoles using a π‐benzylpalladium system on water was developed. The reaction afforded the desired products in moderate to excellent yields from readily available ortho‐phenylenediamines and benzyl alcohols. This base‐free simple protocol can achieve the dehydrogenation of benzyl alcohols under mild conditions, whereas strong bases are essential in general hydrogen‐transfer strategies. Notably, the “on water” protocol is essential for this synthetic method. More information can be found in the Full Paper by Hidemasa Hikawa, Isao Azumaya et al. on page 416 in Issue 2, 2018 (DOI: 10.1002/ajoc.201700618).

中文翻译：

封面人物：钯催化的苄醇在水上建造2-芳基苯并咪唑的脱氢反应（Asian J. Org。Chem。2/2018）

在水上：开发了一种环境友好的单锅串联反应，该反应使用π-苄基钯系统在水上合成2-芳基苯并咪唑。该反应从容易获得的邻苯二胺和苄醇中以中等至优异的收率提供了所需的产物。这种无碱的简单方法可以在温和的条件下实现苄醇的脱氢，而强碱在一般的氢转移策略中是必不可少的。值得注意的是，“水上”协议对于这种合成方法至关重要。更多信息可以在Hidemasa Hikawa，Isao Azumaya等人的论文全文中找到。就在第2期，2018页416（：10.1002 / ajoc.201700618 DOI）。

更新日期：2018-02-08

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