Walking Metals for Remote Functionalization,ACS Central Science

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Walking Metals for Remote Functionalization
ACS Central Science ( IF 12.7 ) Pub Date : 2018-02-08 00:00:00 , DOI: 10.1021/acscentsci.8b00005
Heiko Sommer ₁ , Francisco Juliá-Hernández ₂ , Ruben Martin _{2,

3} , Ilan Marek ₁

Affiliation

The distant and selective activation of unreactive C–H and C–C bonds remains one of the biggest challenges in organic chemistry. In recent years, the development of remote functionalization has received growing interest as it allows for the activation of rather challenging C–H and C–C bonds distant from the initiation point by means of a “metal-walk”. A “metal-walk” or “chain-walk” is defined by an iterative series of consecutive 1,2- or 1,3-hydride shifts of a metal complex along a single hydrocarbon chain. With this approach, simple building blocks or mixtures thereof can be transformed into complex scaffolds in a convergent and unified strategy. A variety of catalytic systems have been developed and refined over the past decade ranging from late-transition-metal complexes to more sustainable iron- and cobalt-based systems. As the possibilities of this field are slowly unfolding, this area of research will contribute considerably to provide solutions to yet unmet synthetic challenges.

中文翻译：

用于远程功能化的行走金属

非反应性 C-H 和 C-C 键的远距离和选择性活化仍然是有机化学中最大的挑战之一。近年来，远程功能化的发展受到越来越多的关注，因为它允许通过“金属行走”激活远离起始点的相当具有挑战性的 C-H 和 C-C 键。“金属行走”或“链行走”定义为金属配合物沿单个烃链的一系列连续 1,2-或 1,3-氢化物位移。通过这种方法，简单的构建块或其混合物可以以收敛和统一的策略转化为复杂的支架。在过去的十年中，已经开发和改进了各种催化系统，从晚期过渡金属配合物到更可持续的铁和钴基系统。

更新日期：2018-02-08

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