Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics,Chemical Society Reviews

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Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-02-08 00:00:00 , DOI: 10.1039/c7cs00479f
Jianliang Shen ₁ , Wei Zhang ₂ , Ruogu Qi ₃ , Zong-Wan Mao ₄ , Haifa Shen ₅

Affiliation

Cancer treatment still faces a lot of obstacles such as tumor heterogeneity, drug resistance and systemic toxicities. Beyond the traditional treatment modalities, exploitation of RNA interference (RNAi) as an emerging approach has immense potential for the treatment of various gene-caused diseases including cancer. The last decade has witnessed enormous research and achievements focused on RNAi biotechnology. However, delivery of small interference RNA (siRNA) remains a key challenge in the development of clinical RNAi therapeutics. Indeed, functional nanomaterials play an important role in siRNA delivery, which could overcome a wide range of sequential physiological and biological obstacles. Nanomaterial-formulated siRNA systems have potential applications in protection of siRNA from degradation, improving the accumulation in the target tissues, enhancing the siRNA therapy and reducing the side effects. In this review, we explore and summarize the role of functional inorganic–organic hybrid systems involved in the siRNA therapeutic advancements. Additionally, we gather the surface engineering strategies of hybrid systems to optimize for siRNA delivery. Major progress in the field of inorganic–organic hybrid platforms including metallic/non-metallic cores modified with organic shells or further fabrication as the vectors for siRNA delivery is discussed to give credit to the interdisciplinary cooperation between chemistry, pharmacy, biology and medicine.

中文翻译：

工程功能性无机-有机混合系统：siRNA 疗法的进展

癌症治疗仍面临肿瘤异质性、耐药性和全身毒性等诸多障碍。除了传统的治疗方式之外，RNA 干扰 (RNAi) 作为一种新兴方法，在治疗包括癌症在内的各种基因引起的疾病方面具有巨大的潜力。过去十年见证了 RNAi 生物技术领域的大量研究和成果。然而，小干扰 RNA (siRNA) 的递送仍然是临床 RNAi 疗法开发中的一个关键挑战。事实上，功能性纳米材料在 siRNA 递送中发挥着重要作用，可以克服一系列的连续生理和生物学障碍。纳米材料配制的siRNA系统在保护siRNA免于降解、改善靶组织中的积累、增强siRNA治疗和减少副作用方面具有潜在的应用。在这篇综述中，我们探索并总结了功能性无机-有机混合系统在 siRNA 治疗进展中的作用。此外，我们还收集了混合系统的表面工程策略以优化 siRNA 递送。讨论了无机-有机混合平台领域的重大进展，包括用有机壳修饰的金属/非金属核或进一步制造作为 siRNA 传递载体，以表彰化学、药学、生物学和医学之间的跨学科合作。

更新日期：2018-02-08

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