Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors.,Neuron

当前位置： X-MOL 学术 › Neuron › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors.
Neuron ( IF 14.7 ) Pub Date : 2018-Feb-07 , DOI: 10.1016/j.neuron.2018.01.006
Nigel S Bamford ₁ , R Mark Wightman ₂ , David Sulzer ₃

Affiliation

Many learned responses depend on the coordinated activation and inhibition of synaptic pathways in the striatum. Local dopamine neurotransmission acts in concert with a variety of neurotransmitters to regulate cortical, thalamic, and limbic excitatory inputs to drive the direct and indirect striatal spiny projection neuron outputs that determine the activity, sequence, and timing of learned behaviors. We review recent advances in the characterization of stereotyped neuronal and operant responses that predict and then obtain rewards. These depend on the local release of dopamine at discrete times during behavioral sequences, which, acting with glutamate, provides a presynaptic filter to select which excitatory synapses are inhibited and which signals pass to indirect pathway circuits. This is followed by dopamine-dependent activation of specific direct pathway circuits to procure a reward. These steps may provide a means by which higher organisms learn behaviors in response to feedback from the environment.

中文翻译：

基于奖励的行为期间多巴胺对皮质纹状体突触的影响。

许多习得的反应取决于纹状体突触通路的协调激活和抑制。局部多巴胺神经传递与多种神经递质协同作用，调节皮质、丘脑和边缘兴奋性输入，驱动直接和间接纹状体棘投射神经元输出，从而决定学习行为的活动、顺序和时间。我们回顾了预测并获得奖励的刻板神经元和操作反应表征的最新进展。这些取决于行为序列期间离散时间多巴胺的局部释放，多巴胺与谷氨酸一起作用，提供突触前过滤器来选择哪些兴奋性突触被抑制以及哪些信号传递到间接通路电路。接下来是特定直接通路回路的多巴胺依赖性激活以获得奖励。这些步骤可能提供了一种手段，使高等生物体能够学习响应环境反馈的行为。

更新日期：2018-02-08

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11