The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two reports by Li et al and Pusapati et al in this issue of Science Signaling provide new insights into the role of GRK2 in HH signaling.

中文翻译：

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刺入平滑信号。

激酶GRK2已与临床上重要的刺猬（HH）信号通路相连，这在信号转导中是矛盾的，但同时也促进了关键HH信号转导子“平滑化”的内在化和降解。Li等人和Pusapati等人在本期《科学信号》杂志上发表的两份报告提供了有关GRK2在HH信号中的作用的新见解。