The study by Oriol Mitjà and colleagues in The Lancet¹ shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;² it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G).

中文翻译：

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偏航性大环内酯类药物

OriolMitjà及其同事在《柳叶刀^{1》上的研究}表明，单轮大规模施用阿奇霉素不足以根除偏航。它也代表了引起偏航的螺旋体螺旋体梅毒螺旋体亚种Pertenue（Tp pertenue）的两个23S rRNA基因突变的首次报道，该突变在5个与流行病学相关的患者中引起了大环内酯类药物的耐药性。先前曾在患有螺旋霉素治疗失败的梅毒患者（由Tp pallidum引起）中报道了A2059G突变。²它是先前在苍白头皮中检测到的两个对大环内酯类有抗药性的突变之一（另一个是A2058G）。