Palladium (Pd)‐loaded poly‐hydromethylsiloxane (PHMS) microparticles of tunable size and elasticity are prepared in a capillary‐based coaxial flow‐focusing microfluidic device constructed using off‐the‐shelf components. Simultaneous droplet formation and chemical cross‐linking processes are performed by tuning the dilution of the cross‐linking catalyst in the annular flow of the microreactor, resulting in PHMS microparticles synthesized in a single step. The size of the elastomeric microparticles can be tuned by adjusting the flow rate ratio of the polymer and cross‐linker mixture to water, while the elasticity can be tuned by the polymer to cross‐linker ratio as well as the flow rate ratio of the polymer mixture to cross‐linking catalyst mixture. Microparticle elasticity is characterized by the degree of solvent uptake. Application of the synthesized PHMS microparticles in organic synthesis is demonstrated by producing monodispersed Pd‐loaded microparticles and utilizing them as microreaction vessels for continuous Suzuki‐Miyaura cross‐coupling in a Pd‐loaded microparticle‐packed bed reactor. © 2018 American Institute of Chemical Engineers AIChE J, 64: 3188–3197, 2018

中文翻译：

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弹性体微粒的微流合成：钯介导的交叉偶联催化的案例研究

在使用现成组件构建的基于毛细管的同轴流聚焦微流体装置中，制备了具有可调大小和弹性的负载钯（Pd）的聚氢甲基硅氧烷（PHMS）微粒。通过调节微反应器环形流中交联催化剂的稀释度，可以同时进行液滴形成和化学交联过程，从而在单个步骤中合成PHMS微粒。可以通过调节聚合物和交联剂混合物与水的流速比来调节弹性体微粒的大小，而可以通过聚合物与交联剂的比率以及聚合物的流速比来调节弹性混合物至交联催化剂混合物。微粒弹性的特征在于溶剂吸收的程度。合成的PHMS微粒在有机合成中的应用通过生产单分散的载Pd微粒并将其用作载有Pd的微粒填充床反应器中连续Suzuki-Miyaura交叉偶联的微反应容器来证明。©2018美国化学工程师学会AIChE J，64：3188-3197，2018