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Versatile Click Cyanine Amino Acid Conjugates Showing One‐Atom‐Influenced Recognition of DNA/RNA Secondary Structure and Mitochondrial Localisation in Living Cells
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-04-16 , DOI: 10.1002/ejoc.201701765
Tamara Šmidlehner 1 , Atanas Kurutos 2 , Jakov Slade 1 , Robert Belužić 1 , Dale L. Ang 3 , Alison Rodger 4 , Ivo Piantanida 1
Affiliation  

Novel amino acids incorporating cyanine dyes in side‐chain show DNA/RNA secondary structure recognition through their fluorescence and CD response, finely tuned by halogen substituents on the cyanine. Some dyes, being non‐toxic, specifically stained mitochondria in living human cells, the triazole amino acid tag behaving as a novel mitochondria‐directing moiety.
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中文翻译:

多功能单击花菁氨基酸缀合物,显示活细胞中一原子影响的DNA / RNA二级结构识别和线粒体定位

在侧链上掺入花青染料的新型氨基酸通过其荧光和CD反应显示出DNA / RNA二级结构识别,并通过花青上的卤素取代基对其进行了微调。有些染料是无毒的,特别是在活的人类细胞中线粒体染色,三唑氨基酸标签表现为一种新颖的线粒体定向部分。
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更新日期:2018-04-16
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