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Tyrosinases in Organic Chemistry: A Versatile Tool for the α‐Arylation of β‐Dicarbonyl Compounds
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-04-19 , DOI: 10.1002/ejoc.201800188
Roxanne Krug 1 , Dennis Schröder 2 , Jan Gebauer 3 , Sanel Suljić 1 , Yuma Morimoto 3 , Nobutaka Fujieda 3 , Shinobu Itoh 3 , Jörg Pietruszka 1, 2
Affiliation  

A tyrosinase‐mediated arylation reaction is presented. Starting from a variety of substituted phenols, the enzyme generates activated o‐quinones, which subsequently can undergo a 1,4‐addition towards the desired arylation products, processing a quaternary center.
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中文翻译:

有机化学中的酪氨酸酶:一种用于β-二羰基化合物α-芳基化的多功能工具

提出了酪氨酸酶介导的芳基化反应。从各种取代的苯酚的开始,酶产生激活ø -quinones,其随后可以经历1,4-加成朝向期望的芳基化产物,加工季中心。
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更新日期:2018-04-19
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