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Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder
Trends in Molecular Medicine ( IF 12.8 ) Pub Date : 2018-02-06 , DOI: 10.1016/j.molmed.2017.12.003
Helen M. Heymann , Adriana M. Gardner , Eric R. Gross

Alcohol use disorder (AUD) screening frequently involves questionnaires complemented by laboratory work to monitor alcohol use and/or evaluate AUD-associated complications. Here we suggest that measuring aldehyde-induced DNA and protein adducts produced during alcohol metabolism may lead to earlier detection of AUD and AUD-associated complications compared with existing biomarkers. Use of aldehyde-induced adducts to monitor AUD may also be important when considering that approximately 540 million people bear a genetic variant of aldehyde dehydrogenase 2 (ALDH2) predisposing this population to aldehyde-induced toxicity with alcohol use. We posit that measuring aldehyde-induced adducts may provide a means to improve precision medicine approaches, taking into account lifestyle choices and genetics to evaluate AUD and AUD-associated complications.



中文翻译:

醛诱导的DNA和蛋白质加合物作为酒精使用障碍的生物标志物工具

饮酒障碍(AUD)筛查通常涉及以实验室工作为辅的问卷调查,以监测饮酒和/或评估AUD相关并发症。在这里,我们建议与现有的生物标志物相比,测量在酒精代谢过程中产生的醛诱导的DNA和蛋白质加合物可能会导致AUD和AUD相关并发症的早期检测。考虑到大约5.4亿人携带醛脱氢酶2(ALDH2)的遗传变异,使用醛诱导的加合物监测AUD也可能很重要。),使这些人群容易因饮酒而产生醛诱导的毒性。我们认为,考虑到生活方式的选择和遗传学来评估AUD和AUD相关并发症,测量醛诱导的加合物可能会提供一种改进精密医学方法的方法。

更新日期:2018-02-06
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