Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems.

中文翻译：

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近红外触发 NiTi 层状双氢氧化物薄膜的晶相转变，用于局部化疗热肿瘤治疗

构建具有协同热热肿瘤杀伤能力的局部药物洗脱系统对于直接接触肿瘤组织的生物医学植入物来说是有希望的。本研究在镍钛诺合金表面制备了一种基于金纳米棒修饰的丁酸盐插入的镍钛层状双氢氧化物薄膜（Au@LDH/B）的智能且生物相容性载药平台。制备的薄膜起到载药“海绵”的作用，在近红外（NIR）照射下泵出丁酸盐，并在近红外激光关闭时重新吸收水中的药物。丁酸盐的刺激响应释放被证实与近红外触发的 Au@LDH/B 晶体相变有关。体外和体内研究表明，所制备的薄膜在协同热化疗肿瘤治疗中具有优异的生物安全性和高效性，在构建局部刺激响应药物递送系统方面显示出良好的应用前景。