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RNA Biomarkers: Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection (Adv. Healthcare Mater. 3/2018)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-02-07 , DOI: 10.1002/adhm.201870013
Mo-Yuan Shen,Jie-Fu Chen,Chun-Hao Luo,Sangjun Lee,Cheng-Hsuan Li,Yung-Ling Yang,Yu-Han Tsai,Bo-Cheng Ho,Li-Rong Bao,Tien-Jung Lee,Yu Jen Jan,Ya-Zhen Zhu,Shirley Cheng,Felix Y. Feng,Peilin Chen,Shuang Hou,Vatche Agopian,Yu-Sheng Hsiao,Hsian-Rong Tseng,Edwin M. Posadas,Hsiao-hua Yu

In article number 1700701, Hsiao‐hua Yu and co‐workers purified circulating tumor cells (CTCs) from blood samples of prostate cancer (PCa) patients. This platform not only captures CTCs with high efficiency and specificity, but also, released these cells gently by a competitive‐binding mechanism. The purified CTCs provide well‐preserved RNA transcripts for the analysis of the expression level of several PCa‐specific RNA biomarkers, which could provide clinical insights into the disease and valuable information for cancer diagnosis and therapeutics.
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中文翻译:

RNA生物标志物:糖皮质激素刺激能够在PEDOT NanoVelcro芯片上纯化前列腺癌循环肿瘤细胞以进行RNA生物标志物检测(Adv。Healthcare Mater.3 / 2018)

于小华及其同事在文章1700701中从前列腺癌(PCa)患者的血液样本中纯化了循环肿瘤细胞(CTC)。该平台不仅可以高效高效地捕获四氯化碳,而且还可以通过竞争结合机制温和释放这些细胞。纯化的四氯化碳提供了保存良好的RNA转录本,可用于分析多种PCa特异性RNA生物标志物的表达水平,这可以为疾病提供临床见解,并为癌症诊断和治疗提供有价值的信息。
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更新日期:2018-02-07
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