Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even cancers. Liver injuries have been a serious public health problem worldwide. Numerous natural products and their bioactive components have shown protective action for liver injuries, such as blueberry, cactus fruits, Pueraria lobate, betaine, and silymarin. The underlying mechanisms mainly include antioxidation, anti‐inflammation, anti‐apoptosis, anti‐necrosis, repairing damaged DNA, regulating the metabolism of lipids, and modulating primary bile acid biosynthesis. This review summarizes the natural products and bioactive compounds with protective effects on liver injuries caused by chemicals, and special attention is paid to the mechanisms of action. This updated information can be helpful to prevent and treat liver‐related diseases, especially chemical‐induced liver injuries.

中文翻译：

---

预防和治疗化学性肝损伤的天然产品

化学药品（例如酒精，药物和污染物）可能会导致肝损伤，从而可能发展为脂肪肝，肝炎，纤维化，肝硬化和肝衰竭，甚至癌症。肝损伤已成为世界范围内严重的公共卫生问题。许多天然产物及其生物活性成分对肝损伤都有保护作用，例如蓝莓，仙人掌果实，葛根叶，甜菜碱和水飞蓟素。潜在的机制主要包括抗氧化，抗炎，抗凋亡，抗坏死，修复受损的DNA，调节脂质的代谢以及调节胆汁酸的生物合成。这篇综述总结了对化学物质引起的肝损伤具有保护作用的天然产物和生物活性化合物，并特别注意其作用机理。这些更新的信息可能有助于预防和治疗肝脏相关疾病，尤其是化学性肝损伤。