An acid-promoted cascade reaction of 4-chloroquinolin-3-yl carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with subsequent Suzuki coupling, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives.

中文翻译：

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4-氯喹啉-3-基氨基甲酸酯与胺的酸促进级联反应：咪唑并[4,5-c]喹啉-2-酮的一锅组装

描述了 4-氯喹啉-3-基氨基甲酸酯与胺的酸促进级联反应。该方法通过分子间胺化/分子内环化反应序列形成两个新的CN键。与随后的 Suzuki 耦合相结合，这种三组件伸缩程序提供了对各种生物活性咪唑并 [4,5-c] quinolin-2-one 衍生物的快速访问。