Nanoceria‐Catalyzed Selective Synthesis of α‐Hydroxy Amides through the Reduction of an Unusual Class of α‐Keto Amides,Asian Journal of Organic Chemistry

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Nanoceria‐Catalyzed Selective Synthesis of α‐Hydroxy Amides through the Reduction of an Unusual Class of α‐Keto Amides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-03-06 , DOI: 10.1002/ajoc.201800007
Ashish A. Mishra ₁ , Bhalchandra M. Bhanage ₁

Affiliation

Herein, we report the preparation of a heterogeneous, efficient, and recyclable ceria nanosphere (NS) catalyst, which was prepared by hydrothermal synthesis with oxalic acid as a capping agent. The morphology and thermal stability of the catalyst were studied by using SEM, XRD, and thermogravimetric analysis (TGA). This nanoceria catalyst was used for the chemoselective hydrogenation of deactivated α‐keto amides by using NaBH₄. This reaction did not work in the absence of the nanoceria catalyst. A series of substituted hydroxy amides were prepared in very good yields with low catalyst loading.

中文翻译：

纳米二氧化铈催化的α-羟基酰胺类选择性还原反应的合成

在本文中，我们报告了一种异质，高效且可回收的二氧化铈纳米球（NS）催化剂的制备，该催化剂是通过以草酸作为封端剂的水热合成法制备的。通过SEM，XRD和热重分析（TGA）研究了催化剂的形貌和热稳定性。该纳米二氧化铈催化剂用于通过NaBH ₄对失活的α-酮酰胺进行化学选择性氢化。在没有纳米氧化铈催化剂的情况下该反应不起作用。以非常好的收率和低的催化剂负载量制备了一系列取代的羟基酰胺。

更新日期：2018-03-06

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