Inflammatory response remains one of the most common and serious complications of disease in clinical studies. It has been established that some molecules found in pomegranate peel polyphenols (PPPs) are related to inflammatory processes; however, the mechanisms are unclear, leaving a significant unmet medical need. The goal of this study was to analyze the anti-inflammatory effects of PPPs in RAW264.7 macrophages and examine the relationship between certain special components such as - punicalagin (PC) and ellagic acid (EA) and systemic inflammation. The results showed that PPPs and their main components PC and EA, could decrease pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) at the mRNA and protein levels and, down-regulate iNOS and COX-2 expression, which in turn reduced NO and PGE₂. The molecular mechanism might be associated with the inhibition of MAPKs activation. Additionally, PPPs and PC performed much better than EA. We highlight the key role of food-derived molecules PPPs and its main components in understanding the mechanism of anti-inflammatory.

在临床研究中，炎症反应仍然是最常见，最严重的疾病并发症之一。已经确定，在石榴皮多酚（PPPs）中发现的某些分子与炎症过程有关；这些分子与炎症过程有关。但是，机制尚不清楚，医疗需求仍未得到满足。这项研究的目的是分析PPPs在RAW264.7巨噬细胞中的抗炎作用，并研究某些特殊成分（例如punicalagin（PC）和鞣花酸（EA））与全身性炎症之间的关系。结果表明，PPP及其主要成分PC和EA可以降低mRNA和蛋白质水平的促炎细胞因子（TNF-α，IL-1β和IL-6），并下调iNOS和COX-2的表达，反过来减少了NO和PGE ₂。分子机制可能与抑制MAPKs激活有关。此外，PPP和PC的性能要比EA好得多。我们强调了食物来源的分子PPPs及其主要成分在了解抗炎机制中的关键作用。