Multifunctional Porous Iron Oxide Nanoagents for MRI and Photothermal/Chemo Synergistic Therapy,Bioconjugate Chemistry

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Multifunctional Porous Iron Oxide Nanoagents for MRI and Photothermal/Chemo Synergistic Therapy
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-02-05 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00052
Yayun Hu ₁ , Hai Hu ₂ , Jun Yan ₃ , Chao Zhang ₁ , Yonggang Li ₄ , Mengyun Wang ₄ , Weiyi Tan ₁ , Jian Liu ₃ , Yue Pan _{1,

2}

Affiliation

Nanoagents of integrating multiple imaging and therapeutic modalities have attracted tremendous attention for biomedical applications. Herein, we synthesize porous hollow Fe₃O₄ as a theranostic agent for MRI and combined photothermal/chemo cancer therapy. The as-prepared porous iron oxide nanoagents allow for T₂-weighted MR imaging. Interestingly, we demonstrate that the porous structure endows the nanoagents an outstanding photothermal property for cancer cell killing, in comparison with other types of iron oxide nanomaterials. Under the exposure of an NIR laser, the heat produced by porous Fe₃O₄ can accelerate the release of the loaded drug (e.g., DOX) to enhance chemotherapeutic efficacy, promoting the ablation of cancer cells with synergistic photothermal/chemotherapy.

中文翻译：

多功能多孔氧化铁纳米剂，用于MRI和光热/化学协同治疗

集成多种成像和治疗方式的纳米剂已引起生物医学应用的极大关注。在这里，我们合成了多孔空心Fe ₃ O ₄作为磁共振成像和光热/化学疗法联合治疗的治疗治疗剂。所制备的多孔氧化铁纳米剂可用于T ₂加权MR成像。有趣的是，与其他类型的氧化铁纳米材料相比，我们证明了多孔结构赋予纳米剂出色的光热特性，可杀死癌细胞。在近红外激光的照射下，多孔Fe ₃ O ₄产生的热量可以加速负载药物（例如DOX）的释放，以增强化疗功效，并通过协同光热/化学疗法促进癌细胞的消融。

更新日期：2018-02-05

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