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Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2018-02-09 00:00:00 , DOI: 10.1021/acs.jproteome.7b00846 Oliver Robinson 1 , Pekka Keski-Rahkonen 2 , Leda Chatzi 3, 4, 5 , Manolis Kogevinas 6, 7, 8 , Tim Nawrot 9, 10 , Costanza Pizzi 11 , Michelle Plusquin 9, 10 , Lorenzo Richiardi 11 , Nivonirina Robinot 2 , Jordi Sunyer 6, 7, 8 , Roel Vermeulen 12 , Martine Vrijheid 6, 7, 8 , Paolo Vineis 1 , Augustin Scalbert 2 , Marc Chadeau-Hyam 1
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2018-02-09 00:00:00 , DOI: 10.1021/acs.jproteome.7b00846 Oliver Robinson 1 , Pekka Keski-Rahkonen 2 , Leda Chatzi 3, 4, 5 , Manolis Kogevinas 6, 7, 8 , Tim Nawrot 9, 10 , Costanza Pizzi 11 , Michelle Plusquin 9, 10 , Lorenzo Richiardi 11 , Nivonirina Robinot 2 , Jordi Sunyer 6, 7, 8 , Roel Vermeulen 12 , Martine Vrijheid 6, 7, 8 , Paolo Vineis 1 , Augustin Scalbert 2 , Marc Chadeau-Hyam 1
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Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. We applied untargeted mass-spectrometry-based metabolomics to 481 cord blood samples collected at delivery in four birth cohorts from across Europe: ENVIRONAGE (Belgium), INMA (Spain), Piccolipiu (Italy), and Rhea (Greece). We performed a metabolome-wide association scan for birth weight on over 4000 metabolic features, controlling the false discovery rate at 5%. Annotation of compounds was conducted through reference to authentic standards. We identified 68 metabolites significantly associated with birth weight, including vitamin A, progesterone, docosahexaenoic acid, indolelactic acid, and multiple acylcarnitines and phosphatidylcholines. We observed enrichment (p < 0.05) of the tryptophan metabolism, prostaglandin formation, C21-steroid hormone signaling, carnitine shuttle, and glycerophospholipid metabolism pathways. Vitamin A was associated with both maternal smoking and birth weight, suggesting a mediation pathway. Our findings shed new light on the pathways central to fetal growth and will have implications for antenatal and perinatal care and potentially for health in later life.
中文翻译：
出生体重的脐带血代谢特征：一项基于人群的研究
出生体重是孕产妇和胎儿健康的重要指标，也是晚年健康的预测指标。然而，人们对出生体重差异的决定因素仍然知之甚少。我们的目的是确定可能受到环境暴露干扰的生物途径，这对于确定出生体重很重要。我们将基于非靶向质谱的代谢组学应用于来自欧洲各地四个出生队列中分娩时收集的 481 份脐带血样本：ENVIR ON AGE（比利时）、INMA（西班牙）、Piccolipiu（意大利）和 Rhea（希腊）。我们对 4000 多个代谢特征进行了出生体重的全代谢组关联扫描，将错误发现率控制在 5%。化合物的注释是通过参考真实标准进行的。我们鉴定出 68 种与出生体重显着相关的代谢物，包括维生素 A、黄体酮、二十二碳六烯酸、吲哚乳酸以及多种酰基肉碱和磷脂酰胆碱。我们观察到色氨酸代谢、前列腺素形成、C21-类固醇激素信号传导、肉碱穿梭和甘油磷脂代谢途径的富集（ p < 0.05）。维生素 A 与母亲吸烟和出生体重有关，这表明存在中介途径。我们的研究结果为胎儿生长的核心途径提供了新的线索，并将对产前和围产期护理以及潜在的晚年健康产生影响。
更新日期：2018-02-09
中文翻译：
出生体重的脐带血代谢特征：一项基于人群的研究
出生体重是孕产妇和胎儿健康的重要指标，也是晚年健康的预测指标。然而，人们对出生体重差异的决定因素仍然知之甚少。我们的目的是确定可能受到环境暴露干扰的生物途径，这对于确定出生体重很重要。我们将基于非靶向质谱的代谢组学应用于来自欧洲各地四个出生队列中分娩时收集的 481 份脐带血样本：ENVIR ON AGE（比利时）、INMA（西班牙）、Piccolipiu（意大利）和 Rhea（希腊）。我们对 4000 多个代谢特征进行了出生体重的全代谢组关联扫描，将错误发现率控制在 5%。化合物的注释是通过参考真实标准进行的。我们鉴定出 68 种与出生体重显着相关的代谢物，包括维生素 A、黄体酮、二十二碳六烯酸、吲哚乳酸以及多种酰基肉碱和磷脂酰胆碱。我们观察到色氨酸代谢、前列腺素形成、C21-类固醇激素信号传导、肉碱穿梭和甘油磷脂代谢途径的富集（ p < 0.05）。维生素 A 与母亲吸烟和出生体重有关，这表明存在中介途径。我们的研究结果为胎儿生长的核心途径提供了新的线索，并将对产前和围产期护理以及潜在的晚年健康产生影响。
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