Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.,ACS Chemical Neuroscience

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Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-02-19 , DOI: 10.1021/acschemneuro.7b00508
Shana M Augustin ₁ , David M Lovinger ₁

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The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.

中文翻译：

中枢神经系统中依赖于内源性大麻素的突触可塑性的功能相关性。

内源性大麻素（eCB）信号系统在涉及动作选择到食欲控制等各种神经功能的大脑区域的短期和长期突触可塑性中起关键作用。本文将探讨eCB在塑造神经回路功能以调节行为中的作用。特别是，我们将讨论eCB介导的在不同大脑区域的长期突触可塑性的行为后果。这篇综述汇集了来自体外和离体研究的证据，并指出了对更多体内研究的需求。

更新日期：2018-02-05

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