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Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-02-05 00:00:00 , DOI: 10.1039/c7bm01113j Po Li 1, 2, 3, 4 , Yue Yan 4, 5, 6, 7, 8 , Binlong Chen 9, 10, 11, 12, 13 , Pan Zhang 1, 2, 3, 4 , Siling Wang 4, 5, 6, 7, 8 , Jing Zhou 1, 2, 3, 4 , Haiming Fan 4, 14, 15, 16 , Yiguang Wang 9, 10, 11, 12, 13 , Xiaonan Huang 1, 2, 3, 4
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-02-05 00:00:00 , DOI: 10.1039/c7bm01113j Po Li 1, 2, 3, 4 , Yue Yan 4, 5, 6, 7, 8 , Binlong Chen 9, 10, 11, 12, 13 , Pan Zhang 1, 2, 3, 4 , Siling Wang 4, 5, 6, 7, 8 , Jing Zhou 1, 2, 3, 4 , Haiming Fan 4, 14, 15, 16 , Yiguang Wang 9, 10, 11, 12, 13 , Xiaonan Huang 1, 2, 3, 4
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In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4:Er3+,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as therapy agents by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency. This work highlights the potential of UCNP@NGO nanocomposites as an integrated theranostic nanoplatform for the UCL image combinatorial PTT of cancer, providing a promising candidate for clinical antitumor treatments.
中文翻译：
镧系元素掺杂的上转换纳米粒子与纳米氧化物石墨烯复合，用于上转换荧光成像和光热疗法†
近年来，多功能纳米颗粒在各种生物医学应用中吸引了许多研究兴趣，例如生物传感器，诊断和药物输送系统。在这项研究中，我们报告了通过复合上转换纳米颗粒（UCNP @ OA）NaLuF 4：Er 3+，Yb 3+开发的NIR成像诊断和治疗纳米平台。与纳米氧化石墨烯（NGO）。所获得的纳米复合材料UCNP @ NGO具有优异的稳定性和低细胞毒性，不仅可以用作肿瘤成像的上转换发光（UCL）探针，而且还可以通过将激光能量转换为热能进行高光热疗法（PTT）的治疗剂。光热转换效率。这项工作强调了UCNP @ NGO纳米复合材料作为癌症的UCL图像组合PTT的综合治疗学纳米平台的潜力，为临床抗肿瘤治疗提供了有希望的候选者。
更新日期：2018-02-05
中文翻译：
镧系元素掺杂的上转换纳米粒子与纳米氧化物石墨烯复合，用于上转换荧光成像和光热疗法†
近年来，多功能纳米颗粒在各种生物医学应用中吸引了许多研究兴趣，例如生物传感器，诊断和药物输送系统。在这项研究中，我们报告了通过复合上转换纳米颗粒（UCNP @ OA）NaLuF 4：Er 3+，Yb 3+开发的NIR成像诊断和治疗纳米平台。与纳米氧化石墨烯（NGO）。所获得的纳米复合材料UCNP @ NGO具有优异的稳定性和低细胞毒性，不仅可以用作肿瘤成像的上转换发光（UCL）探针，而且还可以通过将激光能量转换为热能进行高光热疗法（PTT）的治疗剂。光热转换效率。这项工作强调了UCNP @ NGO纳米复合材料作为癌症的UCL图像组合PTT的综合治疗学纳米平台的潜力，为临床抗肿瘤治疗提供了有希望的候选者。
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