In patients with Fabry disease, neutralizing anti-drug antibodies were identified as IgG4 isotypes. The determination of antibody titers during infusions indicated that high dosages of enzyme overcome anti-drug antibody titers, necessitating individually tailored dose adjustment.

中文翻译：

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法布里病患者输注过程中药物中和抗体的表征

在患有法布里（Fabry）病的患者中，中和性抗药物抗体被鉴定为IgG4同种型。输注过程中抗体滴度的确定表明高剂量的酶克服了抗药物抗体的滴度，因此需要单独调整剂量。