Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor,Molecular Nutrition & Food Research

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Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-03-30 , DOI: 10.1002/mnfr.201700860
Rongxia Liu ₁ , Elke H Heiss ₂ , Birgit Waltenberger ₃ , Tina Blažević ₂ , Daniel Schachner ₂ , Baohong Jiang ₄ , Vladimir Krystof ₅ , Wanhui Liu ₁ , Stefan Schwaiger ₃ , Luis M Peña-Rodríguez ₆ , Johannes M Breuss ₇ , Hermann Stuppner ₃ , Verena M Dirsch ₂ , Atanas G Atanasov _{2,

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Affiliation

Aberrant vascular smooth muscle cell (VSMC) proliferation is involved in atherosclerotic plaque formation and restenosis. Mediterranean spices have been reported to confer cardioprotection, but their direct influence on VSMCs has largely not been investigated. This study aims at examining rosmarinic acid (RA) and 11 related constituents for inhibition of VSMC proliferation in vitro, and at characterizing the most promising compound for their mode of action and influence on neointima formation in vivo.

中文翻译：

地中海香料成分对抗血管平滑肌细胞增殖：新型抑制剂迷迭香酸甲酯的鉴定和表征

异常的血管平滑肌细胞（VSMC）增殖参与动脉粥样硬化斑块的形成和再狭窄。据报道，地中海香料具有心脏保护作用，但其对 VSMC 的直接影响很大程度上尚未得到研究。本研究旨在检测迷迭香酸 (RA) 和 11 种相关成分在体外抑制 VSMC 增殖的作用，并表征最有前途的化合物的作用模式和对体内新内膜形成的影响。

更新日期：2018-03-30

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