Magnesium-based alloys have attracted interest as a potential material to comprise biomedical implants that are simultaneously high-strength and temporary, able to provide stabilization before degrading safely and able to be excreted by the human body. Many alloy systems have been evaluated, but this work reports on improved properties through hot extrusion of one promising alloy: Mg-1.0 wt% Ca-0.5 wt%Sr. This alloy has previously demonstrated promising toxicity and degradation properties in the as-cast and rolled conditions. In the current study extrusion causes a dramatic improvement in the mechanical properties in tension and compression, as well as a low in vitro degradation rate. Microstructure (texture, second phase distribution, and grain size), bulk mechanical properties, flow behavior, degradation in simulated body fluid, and effect on osteoblast cyctotoxicity are evaluated and correlated to extrusion temperature. Maximum yield strength of 300 MPa (above that of annealed 316 stainless steel) with 10% elongation is observed, making this alloy competitive with existing implant materials.

镁基合金作为一种潜在的材料已引起人们的兴趣，该材料包括同时具有高强度和暂时性的生物医学植入物，能够在安全降解之前提供稳定作用，并能被人体排泄。已经评估了许多合金体系，但是这项工作报道了通过热挤压一种有前途的合金改善的性能：Mg-1.0 wt％Ca-0.5 wt％Sr。该合金先前已证明在铸态和轧制条件下具有令人满意的毒性和降解性能。在当前的研究中，挤压导致拉伸和压缩机械性能的显着改善，以及体外降解率低。微观结构（纹理，第二相分布和晶粒尺寸），整体力学性能，流动行为，模拟体液中的降解，评估其对成骨细胞毒性的作用并将其与挤压温度相关联。观察到最大屈服强度为300 MPa（高于退火316不锈钢），伸长率为10％，使该合金与现有植入物材料具有竞争力。