Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)‐platinum(IV) (Pt(IV))‒ZnFe₂O₄, denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near‐infrared light can convert low energy photons to high energy ones, which act as the UV–vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe₂O₄ nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA. The synergistic therapeutic effect is verified in vitro and in vivo results. The cleavage of Pt(IV) from UCNPs during the reduction process can shift the larger UCPZ nanoparticles (NPs) to the smaller ones, which promotes the enhanced permeability and retention (EPR) and deep tumor penetration. In addition, due to the inherent upconversion luminescence (UCL) and the doped Yb³⁺ and Fe³⁺ in UCPZ, this system can serve as a multimodality bioimaging contrast agent, covering UCL, X‐ray computed tomography, magnetic resonance imaging, and photoacoustic. A smart all‐in‐one imaging‐guided diagnosis and treatment system is realized, which should have a potential value in the treatment of tumor.

中文翻译：

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谷胱甘肽介导的可调节大小的UCNPs-Pt（IV）-ZnFe2O4纳米复合材料，用于多种生物成像指导的协同治疗。

此处设计了多功能纳米平台（上转换纳米粒子（UCNPs）-铂（IV）（Pt（IV））‒ ZnFe ₂ O ₄，表示为UCPZ）用于协同癌症治疗，包括光动力疗法（PDT），化学疗法和Fenton反应。在该系统中，由近红外光触发的UCNP可以将低能光子转换为高能光子，这些光子充当UV-vis源，同时介导PDT效应和Fenton对ZnFe ₂ O ₄的反应纳米粒子。同时，癌细胞中的谷胱甘肽可将Pt（IV）前药还原为高毒性Pt（II），后者可与DNA结合并抑制DNA的复制。在体外和体内结果中证实了协同治疗作用。在还原过程中从UCNPs裂解Pt（IV）可以将较大的UCPZ纳米颗粒（NPs）移至较小的纳米颗粒，从而促进增强的通透性和保留（EPR）和深层肿瘤渗透。此外，由于固有的上转换发光（UCL）和掺杂的Yb ³⁺和Fe ³⁺在UCPZ中，该系统可以用作多模态生物成像造影剂，涵盖UCL，X射线计算机断层扫描，磁共振成像和光声。实现了一个智能的多合一影像引导诊断和治疗系统，该系统在肿瘤治疗中应具有潜在价值。