Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics,Small

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Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics
Small ( IF 13.0 ) Pub Date : 2018-02-02 , DOI: 10.1002/smll.201703334
Sung Bong Kim ₁ , Yi Zhang _{2,

3} , Sang Min Won ₁ , Amay J. Bandodkar _{2,

3} , Yurina Sekine ₄ , Yeguang Xue _{5,

6} , Jahyun Koo _{2,

3} , Sean W. Harshman ₇ , Jennifer A. Martin ₇ , Jeong Min Park _{8,

9} , Tyler R. Ray _{2,

3} , Kaitlyn E. Crawford _{1,

10} , Kyu-Tae Lee ₁ , Jungil Choi _{2,

3} , Rhonda L. Pitsch ₁₁ , Claude C. Grigsby ₇ , Adam J. Strang ₁₂ , Yu-Yu Chen ₁ , Shuai Xu _{13,

14} , Jeonghyun Kim ₁₅ , Ahyeon Koh ₁₆ , Jeong Sook Ha ₁₇ , Yonggang Huang _{6,

18} , Seung Wook Kim ₁₇ , John A. Rogers _{2,

3,

6,

19,

20}

Affiliation

Department of Materials Science and Engineering; and Frederick Seitz Materials Research Laboratory; University of Illinois at Urbana-Champaign; Urbana IL 61801 USA
Center for Bio-Integrated Elecctronics at the Simpson Querry Institute for BioNanotechnology; Northwestern University; Evanston IL 60208 USA
Department of Materials Science and Engineering; Northwestern University; Evanston IL 60208 USA
Materials Sciences Research Center; Japan Atomic Energy Agency; Tokai Ibaraki 319-1195 Japan
Department of Civil and Environmental Engineering; Northwestern University; Evanston IL 60208 USA
Department of Mechanical Engineering; Northwestern University; Evanston IL 60208 USA
711th Human Performance Wing; Airman Systems Directorate; Human-Centered ISR Division; Human Signatures Branch Air Force Research Laboratories WPAFB; OH 45433 USA
Department of Physics; Duke University; Durham NC 27708 USA
Department of Chemistry; Duke University; Durham NC 27708 USA
Department of Materials Science and Engineering; University of Central Florida; Orlando FL 32816 USA
Contractor for The Henry M. Jackson Foundation for the Advancement of Military Medicine 711th Human Performance Wing; Airman Systems Directorate; Human-Centered ISR Division; Human Signatures Branch Air Force Research Laboratories WPAFB; OH 45433 USA
Air Force Research Laboratory; Wright-Patterson AFB; OH 45433 USA
Center for Bio-Integrated Electronics; Northwestern University; Evanston IL 60208 USA
Department of Dermatology; Northwestern University; Feinberg School of Medicine; Chicago IL 60611 USA
Department of Electronics Convergence Engineering; Kwangwoon University; Nowon-gu Seoul 01897 Republic of Korea
Department of Biomedical Engineering; Binghamton University; State University of New York; Binghamton NY 13902 USA
Department of Chemical and Biological Engineering; Korea University; Seongbuk-gu Seoul 02841 Republic of Korea
Department of Civil and Environmental Engineering; Department of Mechanical Engineering; Department of Materials Science and Engineering; Northwestern University; Evanston IL 60208 USA
Department of Biomedical Engineering; Northwestern University; Evanston IL 60208 USA
Department of Chemistry; Northwestern University; Evanston IL 60208 USA. Department of Electrical Engineering and Computer Science; Northwestern University; Evanston IL 60208 USA. Department of Neurological Surgery; Northwestern University; Evanston IL 60208 USA. Simpson Querrey Institute for Nano/Biotechnology; McCormick School of Engineering and Feinberg; School of Medicine; Northwestern University; Evanston IL 60208 USA

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin‐mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well‐defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

中文翻译：

高吸收性聚合物阀和比色化学，用于通过皮肤固定的软微流控按时间顺序对汗液进行离散采样和氯化物分析

本文介绍了高吸收性聚合物阀和比色传感试剂，它们是柔软的，安装在皮肤上的微流控设备的组成部分，旨在捕获，存储和化学分析从内分泌腺释放的汗水。阀门技术提供了可靠的手段，可以按明确的顺序将汗水从进口位置引导到隔离储罐的集合中。这些储层中的分析涉及氯化物浓度的颜色响应指示剂，其配方经过专门设计，可提供稳定的操作，并且灵敏度针对相关的生理范围进行了优化。对人类受试者的评估以及与非原位分析的比较说明了这些进展的实际实用性。

更新日期：2018-02-02

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