Cancer cells can directly stimulate the generation and recruitment of tumor-supportive bone marrow-derived cells (BMDCs), including neutrophils, via secreted factors. A new study demonstrates that lung tumors also remotely activate bone-residing osteoblasts, which in turn promote neutrophil production. This is a multistep mechanism of establishing a supportive tumor microenvironment.

中文翻译：

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骨头谈话：活化的成骨细胞促进肺癌的生长

癌细胞可以通过分泌因子直接刺激包括中性粒细胞在内的肿瘤支持性骨髓衍生细胞（BMDC）的产生和募集。一项新的研究表明，肺部肿瘤还可以远程激活留骨的成骨细胞，从而促进中性粒细胞的产生。这是建立支持性肿瘤微环境的多步骤机制。