Detection of Circulating Tumor Cells Using Microfluidics,ACS Combinatorial Science

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Detection of Circulating Tumor Cells Using Microfluidics
ACS Combinatorial Science Pub Date : 2018-01-24 00:00:00 , DOI: 10.1021/acscombsci.7b00146
Tiberiu A. Burinaru ₁ , Marioara Avram ₁ , Andrei Avram ₁ , Cătălin Mărculescu ₁ , Bianca Ţîncu ₁ , Vasilica Ţucureanu ₁ , Alina Matei ₁ , Manuella Militaru ₂

Affiliation

Metastasis is the main cause of death in cancer patients worldwide. During metastasis, cancer cells detach from the primary tumor and invade distant tissue. The cells that undergo this process are called circulating tumor cells (CTCs). Studies show that the number of CTCs in the peripheral blood can predict progression-free survival and overall survival and can be informative concerning the efficacy of treatment. Research is now concentrated on developing devices that can detect CTCs in the blood of cancer patients with improved sensitivity and specificity that can lead to improved clinical evaluation. This review focuses on devices that detect and capture CTCs using different cell properties (surface markers, size, deformability, electrical properties, etc.). We also discuss the process of tumor cell dissemination, the biology of CTCs, epithelial–mesenchymal transition (EMT), and several challenges and clinical applications of CTC detection.

中文翻译：

使用微流控技术检测循环肿瘤细胞

转移是全世界癌症患者死亡的主要原因。在转移过程中，癌细胞会从原发肿瘤中脱离出来并侵入远处的组织。经历此过程的细胞称为循环肿瘤细胞（CTC）。研究表明，外周血中四氯化碳的数量可以预测无进展生存期和总生存期，并且可以提供有关治疗功效的信息。现在的研究集中在开发可以检测癌症患者血液中CTC的设备，这些设备具有提高的敏感性和特异性，从而可以改善临床评估。这篇综述着重于使用不同细胞特性（表面标记，大小，可变形性，电特性等）检测和捕获四氯化碳的设备。我们还将讨论肿瘤细胞的传播过程，四氯化碳的生物学，

更新日期：2018-01-24

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