Cardiac Tissue Engineering on the Nanoscale,ACS Biomaterials Science & Engineering

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Cardiac Tissue Engineering on the Nanoscale
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-02-02 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00913
Ranjith Kumar Kankala _{1,

2} , Kai Zhu _{3,

4} , Xiao-Ning Sun _{3,

4} , Chen-Guang Liu ₁ , Shi-Bin Wang _{1,

2} , Ai-Zheng Chen _{1,

2}

Affiliation

In recent years, the fabrication of smart materials at an arbitrary gauge has attracted enormous interest from researchers in the tissue engineering (TE) field. This potential tool has been utilized for the generation of various biomimetic/bioinspired structures to repair and improve the performance of the injured tissues. Cardiac TE is one of them that offers immense benefits in treating various cardiovascular diseases, such as myocardial infarction (MI). Currently, various nanoparticles have been utilized alone or by incorporating them in hydrogels or other biomimetic scaffolds to mimic the morphological and electrophysiological characteristics of native cardiac tissue for a better regenerative outcome. Herein, we aim to give a brief overview, which provides an emphasis and discussion of the latest reports on these innovative nanoconstructs intended for cardiac TE. Finally, we summarize the existing challenges and prospects of the cardiac TE field.

中文翻译：

纳米级心脏组织工程

近年来，以任意规格制造智能材料引起了组织工程（TE）领域研究人员的极大兴趣。这种潜在的工具已被用于生成各种仿生/生物启发的结构，以修复和改善受伤组织的性能。心脏TE是其中一种在治疗各种心血管疾病（例如心肌梗塞（MI））方面具有巨大优势的产品。当前，各种纳米颗粒已经被单独使用或通过将它们掺入水凝胶或其他仿生支架中以模拟天然心脏组织的形态和电生理特性以获得更好的再生结果。在此，我们旨在简要概述一下，其中重点和讨论了有关用于心脏TE的创新纳米结构的最新报告。最后，我们总结了心脏TE领域的现有挑战和前景。

更新日期：2018-02-02

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